Tamanna Sahni (Shilpa Shetty) is a dedicated staff member of a top advertising agency; her ideas and designs have mainly contributed to the agency's success. She leaves for a college reunion and meets her college sweetheart Rohit (Salman Khan). They rekindle their love and share some intimate moments. Eventually Rohit leaves and Tamanna settles back into her daily routine. When her sister Tanya has an accident she decides to give her own blood to save her, until Dr. Raisingh (Revathi) tells her she has tested positive for HIV. Tamanna's world turns upside-down and she desperately tries to contact Rohit, but in vain. Her situation is soon spread around the office and she loses her job. Angered by her unfair dismissal she searches for a lawyer to fight her case. Eventually Tarun Anand (Abhishek Bachchan) agrees to represent her. The rest of the story shows if Tarun can help destroy the prejudice put upon Tamanna.